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    Technology

    Introducing
    Piezoelectric Regeneration

    Bone regeneration is mechanical.

    Oral Biolife has developed the first piezoelectric regenerative platform that restores bone by converting endogenous mechanical forces into localized bioelectric signaling that activates physiological osteogenesis.

    The Science

    The Piezoelectric Effect

    Bone is naturally piezoelectric. When exposed to mechanical stress, it generates electrical potentials that regulate osteogenesis.

    Modern medicine has attempted to induce bone regeneration chemically or surgically. This mismatch between biology and intervention explains why outcomes remain inconsistent, unpredictable, and invasive.

    Oral Biolife is the first company to clinically harness piezoelectricity to activate bone regeneration at its source.

    Extreme microscopic view of cellular interaction
    Mechanism

    How The Platform Works

    01

    Place

    A photo-crosslinked scaffold conforms to the bone defect

    02

    Activate

    Daily micromotion generates localized therapeutic bioelectrical signaling

    03

    Regenerate

    New bone forms as the scaffold biodegrades

    No external energy. No drugs. No biologics.

    Only endogenous mechanical energy, precisely directed.

    Piezoelectric bone regeneration validation
    Validation

    Validation and Safety

    We have demonstrated 100% bone regeneration response in pre-clinical canine ligature models, with multi-species confirmation of piezoelectric mechanotransduction.

    The platform exhibits a clean safety profile, consistent with decades of clinical use of electro-mechanical stimulation in bone healing, without the risks associated with pharmacologic or biologic agents.

    Advantages

    Why Piezoelectric Wins

    Oral Biolife is the only non-surgical technology that enables predictable, physics-driven bone regeneration.

    Mechanical Mechanism

    Predictable, durable, and tunable activation through physics, not chemistry.

    Endogenous Activation

    No growth factors, drugs, or cells. Uses the body's own mechanical energy.

    Localized Signaling

    Controlled, site-specific bioelectrical signals for precise regeneration.

    Self-Powered

    Uses forces already present in the body—no external energy required.

    Clean Regulatory

    Strong animal-to-human translation with decades of supporting clinical use.

    Applications

    A Tunable Regenerative Platform

    Our piezoelectric scaffold platform is tunable across bone-forming environments, enabling expansion into:

    Periodontal Bone DefectsLead Program
    Peri-implantitisPreclinical
    Craniofacial RegenerationPlatform Expansion
    Orthopedic ApplicationsPlatform Expansion

    Built for Bone That Can't Heal on Its Own

    Oral Biolife is redefining bone regeneration by engineering the signals that biology already understands.

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